The diagnostic criteria for probable DLB require:
- The presence of dementia
-
At least two of three core features:
- fluctuating attention and concentration,
- recurrent well-formed visual hallucinations, and
- spontaneous parkinsonian motor signs.
Suggestive clinical features include:
- Rapid eye movement (REM) sleep behavior disorder
- Severe neuroleptic sensitivity
- Low dopamine transporter uptake in basal ganglia demonstrated by SPECT or PET imaging
In the absence of two core features, the diagnosis of probable DLB can also be made if dementia plus at least one suggestive feature is present with one core feature.
Possible DLB can be diagnosed with the presence of dementia plus one core or suggestive feature.
Supportive clinical features include repeated falls, syncope, a
transient loss of consciousness, severe autonomic dysfunction,
depression, systematized delusions, or hallucinations in other sensory
and perceptual modalities.While these features may support the clinical
diagnosis, they lack diagnostic specificity and can be seen in other
neurodegenerative disorders.
